Date of Award
Spring 2024
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Psychology
Committee Chairperson
Kristen R. Breit, Ph.D.
Committee Member
Susan E. Gans, Ph.D.
Committee Member
Aaron Rundus, Ph.D.
Committee Member
Eric Sweet, Ph.D.
Abstract
Thirty percent of people who report consumption of alcohol while pregnant simultaneously report consuming nicotine. Prenatal co-exposure to alcohol and nicotine has increased with the popularity of electronic cigarettes due to their presumed safety, yet e-cigarette use may have a greater impact on fetal development than traditional cigarettes. Prenatal exposure to alcohol or nicotine is associated with increased anxiety-related behaviors and impaired motor coordination later in life, yet it is unknown whether prenatal co-exposure to alcohol and nicotine exacerbates these effects, particularly via e-cigarettes. This project examined the effects of co-exposure to alcohol and nicotine via e-cigarettes during early development on anxiety- and motor-related behaviors later in life using a mouse model. Maternal mice and their neonates were exposed to alcohol, nicotine, the combination, or the e-cigarette vehicle from postnatal days (PD) 4-9, mimicking the human 3rd trimester brain growth spurt. Offspring were examined for anxiety- and motor-related behaviors in adolescence. Developmental exposure to either alcohol or nicotine via e-cigarettes increased anxiety-related behaviors on the elevated plus maze. Developmental alcohol exposure also impaired habituation to the open field, while only developmental co-exposure to alcohol and nicotine via e-cigarettes significantly decreased locomotor activity. Lastly, developmental exposure to nicotine via e-cigarettes alone altered spatial memory and motor coordination in a sex-dependent manner, in which males and females showed advanced trajectories for spatial memory and motor learning, respectively. Overall, these data suggest that alcohol and e-cigarettes may have domain- and sex-specific effects on behavior, and co-exposure to these drugs have unique interactive effects.
Recommended Citation
Cirafesi, Carley, "The Effects of Early Developmental Co-Exposure to Alcohol and Nicotine via E-Cigarettes on Anxiety- and Motor-Related Behaviors in Mice" (2024). West Chester University Master’s Theses. 309.
https://digitalcommons.wcupa.edu/all_theses/309