Ten adult volunteers participated in 16 weeks of cardiovascular exercise training (EG) to determine the effects of training on resting prostacyclin (PGI(2)) and thromboxane A(2) (TXA(2)). Six volunteers of similar age served as sedentary controls (CG). Blood was collected in tubes after training and eicosanoids were measured by standard I-125 RIA methods. Over the 16 weeks of the study, PGI(2) decreased 48% for EG and 33% for CG. There were no between-group differences for PGI(2) values. No significant within-group changes in TXA(2) were found, whereas between-group pretraining TXA(2) values were significantly different. A time main effect for PGI(2) may indicate a seasonal shift in this eicosanoid; however, the additional 15% decrease in PGI(2) for EG may be due to a training-induced reduction in PGI(2) substrate and/or endothelial sensitivity to agonists. The lack of within-group changes in TXA(2) may be due to a combination of high platelet turnover and a training stimulus inadequate to alter platelet function.
Journal of Aging and Physical Activity
Human Kinetics Publishing Inc
Kauffman, R. D., Sforzo, G. S., Frost, B., & Todd, M. K. (1997). The Effects of Exercise Training on Resting Prostacyclin and Thromboxane A(2) in Older Adults. Journal of Aging and Physical Activity, 5(1), 59-70. Retrieved from http://digitalcommons.wcupa.edu/chem_facpub/5